Báo cáo khoa học: Chronic high-dose morphine treatment promotes SH-SY5Y cell apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway
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Chronic high doses of morphine inhibit the growth of various humancancer cell lines. However, the mechanisms by which such high-dosemorphine inhibits cell proliferation and induces cell death are not fullyunderstood. Here we show that c-Jun N-terminal kinase (JNK) plays apivotal role in high-dose morphine-induced apoptosis of SH-SY5Y cells ina mitochondria-dependent manner.
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Báo cáo khoa học: Chronic high-dose morphine treatment promotes SH-SY5Y cell apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Chronic high-dose morphine treatment promotes SH-SY5Y cell apoptosis via c-Jun N-terminal kinase-mediated activation of mitochondria-dependent pathway
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