Báo cáo khoa học: Comparison of the inward- and outward-open homology models and ligand binding of human P-glycoprotein
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An homology model of human P-glycoprotein, based on the X-ray struc-ture of the recently resolved mouse P-glycoprotein, is presented. Themodel corresponds to the inward-facing conformation competent for drugbinding. From the model, the residues involved in the protein-binding cav-ity are identified and compared with those in the outward-facing confor-mation of human P-glycoprotein developed previously based on theSav1866 structure.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Comparison of the inward- and outward-open homology models and ligand binding of human P-glycoprotein
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Comparison of the inward- and outward-open homology models and ligand binding of human P-glycoprotein
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