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Báo cáo khoa học: Expressed as the sole Hsp90 of yeast, the a and b isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90b generates sensitivity to the Hsp90 inhibitor radicicol
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Heat shock protein 90 (Hsp90) is a molecular chaperone required for theactivity of many of the most important regulatory proteins of eukaryoticcells (the Hsp90 ‘clients’). Vertebrates have two isoforms of cytosolicHsp90, Hsp90aand Hsp90b. Hsp90bis expressed constitutively to a highlevel in most tissues and is generally more abundant than Hsp90a, whereasHsp90a is stress-inducible and overexpressed in many cancerous cells.
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Expressed as the sole Hsp90 of yeast, the a and b isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90b generates sensitivity to the Hsp90 inhibitor radicicol
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Expressed as the sole Hsp90 of yeast, the a and b isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90b generates sensitivity to the Hsp90 inhibitor radicicol
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