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Báo cáo khoa học: Expression of the Drosophila melanogaster ATP synthase a subunit gene is regulated by a transcriptional element containing GAF and Adf-1 binding sites

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Mitochondrial biogenesis is a complex and highly regulatedprocess that requires the controlled expression of hundredsof genes encoded in two separated genomes, namely thenuclear and mitochondrial genomes. To identify regulatoryproteins involved in the transcriptional control of key nuc-lear-encoded mitochondrial genes, we have performed adetailed analysis of the promoter region of theasubunit ofthe Drosophila melanogasterF1F0ATP synthase complex.Using transient transfection assays, we have identified a56 bpcis-acting proximal regulatory region that containsbinding sites for the GAGA factor and the alcohol dehy-drogenase distal factor 1....
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Báo cáo khoa học: Expression of the Drosophila melanogaster ATP synthase a subunit gene is regulated by a transcriptional element containing GAF and Adf-1 binding sites

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