Báo cáo khoa học: High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine
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Butyrylcholinesterase is a serine esterase, closely related toacetylcholinesterase. Both enzymes employ a catalytic triadmechanism for catalysis, similar to that used by serine pro-teases such as a-chymotrypsin. Enzymes of this type aregenerally considered to be inactive at pH values below 5,because the histidine member of the catalytic triad becomesprotonated. We have found that butyrylcholinesteraseretains activity at pH £ 5, under conditions of excesssubstrate activation.
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Báo cáo khoa học: High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine
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Báo cáo khoa học: High activity of human butyrylcholinesterase at low pH in the presence of excess butyrylthiocholine
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