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Báo cáo khoa học: Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways Based on The Anniversary Prize of the Gesellschaft fu¨r Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels
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One of the hallmarks of cAMP is its ability to inhibit proliferation in manycell types, but stimulate proliferation in others. Clearly cAMP has cell typespecific effects and the outcome on proliferation is largely attributed tocrosstalk from cAMP to the RAS⁄RAF⁄mitogen-activated protein kinase(MAPK) and extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK pathway. We review the crosstalk between these two ancient and con-served pathways, describing the molecular mechanisms underlying theinteractions between these pathways and discussing their possible biologicalimportance....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways Based on The Anniversary Prize of the Gesellschaft fu¨r Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways Based on The Anniversary Prize of the Gesellschaft fu¨r Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels
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