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Báo cáo khoa học: Long-distance interactions between enhancers and promoters The case of the Abd-B domain of the Drosophila bithorax complex

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Abdominal-B(Abd-B) is a complex homeotic gene with a difficult task: onetranscript determines the identity of four different abdominal segmentsthroughout development in Drosophila. Although an increasing amount ofinformation is available about the structure and the functioning of the reg-ulatory regions that determine the expression pattern ofAbd-B, it is stillnot clear how these regulatory regions can contact the distantly located(several tens of kilobases away) promoter in the nucleus, what mechanismrestricts promiscuous enhancers to this specific interaction, and how differ-ent regulatory regions replace one another at the same promoter in subse-quent abdominal segments....
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Báo cáo khoa học: Long-distance interactions between enhancers and promoters The case of the Abd-B domain of the Drosophila bithorax complex

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