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Báo cáo khoa học: MR solution structure of the precursor for carnobacteriocin B2, an antimicrobial peptide fromCarnobacterium piscicola Implications of the a-helical leader section for export and inhibition of type IIa bacteriocin activity

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Type IIa bacteriocins, which are isolated from lactic acidbacteria that are useful for food preservation, are potentantimicrobial peptides with considerable potential astherapeutic agents for gastrointestinal infections in mam-mals. They are ribosomally synthesized as precursors withan N-terminal leader, typically 18–24 amino acid residuesin length, which is cleaved during export from the produ-cing cell. We have chemically synthesized the full precursorof carnobacteriocin B2, precarnobacteriocin (preCbnB2),which has a C-terminal amide rather than a carboxyl, andalso produced preCbnB2(1–64), ...
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Báo cáo khoa học: MR solution structure of the precursor for carnobacteriocin B2, an antimicrobial peptide fromCarnobacterium piscicola Implications of the a-helical leader section for export and inhibition of type IIa bacteriocin activity

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