Danh mục

Báo cáo khóa học: Noncytotoxic ribonuclease, RNase T1, induces tumor cell death via hemagglutinating virus of Japan envelope vector

Số trang: 6      Loại file: pdf      Dung lượng: 300.42 KB      Lượt xem: 6      Lượt tải: 0    
Xem trước 2 trang đầu tiên của tài liệu này:

Thông tin tài liệu:

Several ribonucleases, including onconase anda-sarcin, areknown to be toxic to tumor cells. On the other hand,although its structure is relatedto thatofa-sarcin,RNase T1is noncytotoxic because of its inability to internalize intotumor cells. In this study, we internalized RNase T1 intohuman tumor cells via a novel gene transfer reagent, hem-agglutinating virus of Japan (HVJ) envelope vector, whichresulted in cell death. This cytotoxicity was drasticallyincreased by pretreatment of HVJ envelope vector withprotamine sulfate, and was stronger than that of onconase,which is inphase III human clinical trials as a nonmutageniccancer chemotherapeutic agent. ...
Nội dung trích xuất từ tài liệu:
Báo cáo khóa học: Noncytotoxic ribonuclease, RNase T1, induces tumor cell death via hemagglutinating virus of Japan envelope vector

Tài liệu được xem nhiều:

Tài liệu liên quan: