Báo cáo khoa học: Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines
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The leptin receptor (LEPR) is a class I cytokine receptor signalling viaboth the janus kinase⁄signal transducer and activator of transcription(JAK⁄STAT) and the MAP kinase pathways. In addition, leptin has beenshown previously to activate AMP-activated kinase (AMPK) in skeletalmuscle. To enable a detailed analysis of leptin signalling in pancreatic betacells, LEPR point mutants with single or combined exchanges of the threeintracellular tyrosines were expressed in HIT-T15 insulinoma cells....
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Báo cáo khoa học: Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines
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Báo cáo khoa học: Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines
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