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Báo cáo khoa học: Protection of chylomicron remnants from oxidation by incorporation of probucol into the particles enhances their uptake by human macrophages and increases lipid accumulation in the cells
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The effects of protection of chylomicron remnants fromoxidation on their uptake and induction of lipid accumula-tion in macrophages were investigated using chylomicronremnant-like particles (CRLPs) containing the lipophilicantioxidant drug, probucol, andmacrophages derived fromthehumanmonocyte cell line,THP-1.The total lipidcontentof THP-1 macrophages was markedly higher (·2.2) after48 h of incubation of THP-1 macrophages with CRLPscontaining probucol (pCRLPs) when compared to CRLPswithout probucol, and this was because of increases in tri-acylglycerol (·2.3) and cholesterol (·1.8) levels, while cho-lesteryl ester concentrations were not significantly changed....
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Báo cáo khoa học: Protection of chylomicron remnants from oxidation by incorporation of probucol into the particles enhances their uptake by human macrophages and increases lipid accumulation in the cells
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Protection of chylomicron remnants from oxidation by incorporation of probucol into the particles enhances their uptake by human macrophages and increases lipid accumulation in the cells
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