Báo cáo khoa học: RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange
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The highly conserved RasGEF1 family of proteins contain a C-terminalCDC25-Ras exchange motif domain and an N-terminal RasGEF-Ndomain, and are of unknown function and specificity. Using purified Ras-GEF1A and RasGEF1B proteins, as well as Ras family proteins, we estab-lished that RasGEF1A and RasGEF1B function as very specific exchangefactors for Rap2, a member of the Rap subfamily of Ras-like G-proteins.
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Báo cáo khoa học: RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange
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