Báo cáo khoa học: Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model
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The tumor suppressor p16INK4ahas functions beyond cell-cycle control viacyclin-dependent kinases. A coordinated remodeling ofN- and O-glycosyla-tion, and an increase in the presentation of the endogenous lectin galectin-1 sensing these changes on the surface of p16INK4a-expressing pancreaticcarcinoma cells (Capan-1), lead to potent pro-anoikis signals.
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Báo cáo khoa học: Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Tumor suppressor p16INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model
Tìm kiếm theo từ khóa liên quan:
Scientific reports scientific research biochemistry The tumor suppressor p16 INK4a has functions beyond cell-cycle control via cyclin-dependent kinases. A coordinated remodeling ofN- and O-glycosyla-tion and an increase in the presentation of the endogenous lectin galectin-1 sensing these changes on the surface of p16 INK4a -expressing pancreatic carcinoma cells (Capan-1) lead to potent pro-anoikis signals.Tài liệu liên quan:
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