Báo cáo y học: Cystic fibrosis and renal disease: a case report

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Cystic fibrosis and renal disease: a case report...
Nội dung trích xuất từ tài liệu:
Báo cáo y học: "Cystic fibrosis and renal disease: a case report"Journal of Medical Case Reports BioMed Central Open AccessCase reportCystic fibrosis and renal disease: a case reportBaha A Al-Shawwa* and Aparna R RaoAddress: Department of Pediatrics, Medical College of Wisconsin (Pulmonary Section), Childrens Hospital of Wisconsin, 9000 West WisconsinAvenue, MS # B620, Milwaukee, WI 53226, USAEmail: Baha A Al-Shawwa* - balshaww@mcw.edu; Aparna R Rao - arrao@mcw.edu* Corresponding authorPublished: 4 June 2007 Received: 10 April 2007 Accepted: 4 June 2007Journal of Medical Case Reports 2007, 1:24 doi:10.1186/1752-1947-1-24This article is available from: http://www.jmedicalcasereports.com/content/1/1/24© 2007 Al-Shawwa and Rao; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Cystic fibrosis (CF) is an autosomal recessive disease that is predominantly seen in the Caucasian population and involves multiple organs. Traditionally it has been thought that the kidney is the only organ which does not seem to be generally affected by the disease although the cystic fibrosis transmembrane conductance regulator (CFTR) gene is expressed in the kidney. Case presentation: We report the case of an 11 year old boy with cystic fibrosis and nephrotic syndrome and review the literature that describes nephrotic syndrome and renal involvement in cystic fibrosis. Conclusion: With continued advances in the management of cystic fibrosis and improvement in life expectancy, several unrecognized co-morbidities are expected to emerge. It is important to screen patients for possible co-morbidities. Urine analysis may be helpful in this group of patients and any proteinuria should raise the suspicion of cystic fibrosis-related renal disease. and nephrotic syndrome. We also review the literatureBackgroundCystic fibrosis (CF) is a multisystem disease characterized about renal involvement in CF.by chronic respiratory infections and exocrine pancreaticinsufficiency. Recent advancement in therapy has lead to Case presentation An 11 year old male with CF (homozygous for ∆F508),improvement in survival. Currently, the median age for apatient with CF is the early 30s [1]. CF is no longer only mild lung disease and pancreatic insufficiency presenteda pediatric disease and long term complications are being with facial swelling that progressed to generalized ana-more frequently reported in adults. sarca over four days. There was a history of preceding upper respiratory symptoms. He denied any change in hisPatients with CF usually present with symptoms involving urine color or bowel habit and there was no history ofthe respiratory and gastrointestinal systems. However, headache, visual disturbance, jaundice, chest pain or pal-other systems can be involved in CF including the renal pitation. The patient remained on his regular medicationssystem. Traditionally the only abnormalities associated which included albuterol, multivitamins and pancreaticwith the renal tract are nephrolithiasis [2,3] and mechan- enzymes.ical urological problems associated with coughing [4]. Inthis case report, we describe a patient with cystic fibrosis He was admitted with similar symptoms 6 months prior to this admission. At that time he had hypoalbuminemia Page 1 of 3 ...