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Báo cáo Y học: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells

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Zinc (Zn), an endogenous regulator of apoptosis, and hasabilitiesboth to induceapoptosis and inhibit the inductionofapoptosis via the modulation of caspase activity. Due to themultifunctions of Zn, the intracellular Zn level is strictlyregulated by a complex system in physiological and patho-logical conditions. The commitment of Zn to the regulationof apoptosis is not fully understood. In the present study, weinvestigated the role of intracellular Zn level in the inductionof apoptosis in human leukemia cells (HL-60 cells) using aZn ionophore [pyrithione (Py)]....
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Báo cáo Y học: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells

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