CLINICAL PHARMACOLOGY 2003 (PART 1)

Professor D. R. Laurence was either author or coauthorof this textbook from its 1st edition in 1960 toits 8th in 1997. This is a long life for any textbook. Itsachievement bears testimony to a style of presentationthat strives to be clear and readable, andto retain the readers interest whilst impartinginformation about a subject that can be at timesboth complex and confusing. As he withdraws fromactive involvement in the book it is opportune topay tribute in this 9th edition to an achievement inauthorship sustained over four decades, duringwhich Laurences pharmacology became the aid,advisor and companion to generations of studentsand doctors seeking...
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CLINICAL PHARMACOLOGY 2003 (PART 1)CLINICALPHARMACOLOGYNature is not only odder than we think, but it is odder than wecan think. J B S Haldane 1893-1964Patients may recover in spite of drugs or because of them. J H Gaddum 1959But know also, man has an inborn craving for medicine ... thedesire to take medicine is one feature which distinguishes manthe animal, from his fellow creatures. It is really one of the mostserious difficulties with which we have to contend ... the doctorsvisit is not thought to be complete without a prescription. William Osier 1894Morals do not forbid making experiments on ones neighbour oron ones self ... among the experiments that may be tried on man,those that can only harm are forbidden, those that are innocentare permissible, and those that may do good are obligatory. Menwho have excessive faith in their theories or ideas are not only illprepared for making discoveries; they make very poorobservations ... they can see in [their] results only a confirmationof their theory ... This is what made us say that we must nevermake experiments to confirm our ideas, but simply to controlthem. Empiricism is not the negation of science, as certainphysicians seem to think; it is only its first stage.Medicine is destined to get away from empiricism little by little;like all other sciences, it will get away by the scientific method.Considered in itself, the experimental method is nothing butreasoning by whose help we methodically submit our ideas toexperience — the experience of facts. Claude Bernard 1865I do not want two diseases — one nature-made, one doctor-made. Napoleon Bonaparte 1820The ingenuity of man has ever been fond of exerting itself tovaried forms and combinations of medicines. William Withering 1785All things are poisons and there is nothing that is harmless, thedose alone decides that something is no poison. Paracelsus 1493-1541First do no harm.It is a good remedy sometimes to use nothing. Hippocrates 460-355 B.C.CLINICALPHARMACOLOGYP. N. Bennett MD FRCPReader in Clinical Pharmacology, University of Bath, and Consultant Physician, Royal United Hospital,Bath, UKM. J. Brown MA MSC MD FRCPProfessor of Clinical Pharmacology, University of Cambridge; ConsultantPhysician, Addenbrookes Hospital, Cambridge and Director of Clinical StudiesGonville and Caius College, Cambridge, UKNINTH EDITION CHURCHILL LIVINGSTONEEDINBURGH LONDON NEW YORK OXFORD PHILADELPHIA ST LOUIS SYDNEY TORONTO 2003CHURCHILL LIVINGSTONE Commissioning Editor: Timothy HomeAn imprint of Elsevier Science Limited Project Development Manager: Colin Arthur Copy Editor: Leslie Smillie© D. R. Laurence 1960,1962,1966,1973 Project Controller: Nancy Arnott© D. R. Laurence and P. N. Bennett 1980,1987,1992 Designer: Erik Bigland© D. R. Laurence, P. N. Bennett, M. J. Brown 1997© P. N. Bennett, M. J. Brown 2003The right of P N Bennett and M J Brown to be identified asthe authors of this work has been asserted by them inaccordance with the Copyright, Designs and Patents Act1988.No part of this publication may be reproduced, stored in aretrieval system, or transmitted in any form or by any means,electronic, mechanical, photocopying, recording orotherwise, without either the prior permission of thepublishers or a licence permitting restricted copying in theUnited Kingdom issued by the Copyright Licensing Agency,90 Tottenham Court Road, London WIT 4LP. Permissionsmay be sought directly from Elseviers Health SciencesRights Department in Philadelphia, USA: phone: (+1) 215 2387869, fax: (+1) 215 238 2239, e-mail:healthpermissions@elsevier.com. You may also completeyour request on-line via the Elsevier Science homepage(http://www.elsevier.com), by selecting Customer Supportand then Obtaining Permissions.First edition 1960 Previous editions translated intoSecond edition 1962 Italian, Chinese, Spanish,Third edition 1966 Serbo-Croat, RussianFourth edition 1973Fifth edition 1980Sixth edition 1987Seventh edition 1992Eighth edition 1997Standard edition ISBN 0443064806International Student Edition ISBN 0443064814British Library Cataloguing in Publication DataA catalogue record for this book is available from theBritish LibraryLibrary of Congress Cataloging in Publication DataA catalog record for this book is available from theLibrary of Congress The publishers ...