Further Study on Chemical Constituents of Croton tonkinensis Gagnep., Euphorbiaceae

Croton tonkinensis Gagnep., commonly named in Vietnamese as "Kho sam Bac Bo", is a tropical shrub native to the Northern Vietnam. Its dried leaves (Folium Tonkinensis) have been used in Vietnamese traditional medicine to treat boils, abscesses, impetigo, abdominal pain, dyspepsia, dysentery, gastric and duodenal ulcers [1, 2]. The plant is of our interest since its varied biological activities demonstrated in our various in vitro bioassays including anti-inflammatory, anticancer, antiplasmodial, antibacterial and antifungal.
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Further Study on Chemical Constituents of Croton tonkinensis Gagnep., EuphorbiaceaeJournal of Chemistry, Vol. 41, No. 1, P. 1, 2003short communication: Further Study on Chemical Constituents of Croton tonkinensis Gagnep., Euphorbiaceae Received 15-2-2003 Phan Minh Giang , Jung Joon Lee2, Phan Tong Son1 1 1 Faculty of Chemistry, Vietnam National University, Hanoi 2 Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology Croton tonkinensis Gagnep., commonly and ent-7 -hydroxy-15-oxokaur-16-en-18-ylnamed in Vietnamese as Kho sam Bac Bo, is a acetate (5.6%). The phytosterols -sitosterol,tropical shrub native to the Northern Vietnam. Its stigmasterol and two long chain alkyl alcoholsdried leaves (Folium Tonkinensis) have been used were also isolated from the non-polar parts of thein Vietnamese traditional medicine to treat boils, methanol extract.abscesses, impetigo, abdominal pain, dyspepsia,dysentery, gastric and duodenal ulcers [1, 2]. The Acknowledgements: The authors are grateful toplant is of our interest since its varied biologicalactivities demonstrated in our various in vitro International Foundation for Science (IFS,bioassays including anti-inflammatory, anti- Stockholm, Sweden) and the National Basiccancer, antiplasmodial, antibacterial and Research Program in Natural Sciences for theantifungal. financial support for this work. Previously we reported on the isolation and Referencesstructural determination of a new diterpenoid ent-7 -hydroxy-15-oxokaur-16-en-18-yl acetate [3,4] 1. Vo Van Chi. Dictionary of Vietnamesefrom the ethanol extract of the leaves of C. Medicinal Plants, Medicine Publishingtonkinensis. Investigation of the methanol extract House, HCM City, P. 622 - 623 (1997).of the leaves of C. tonkinensis by HPLC coupled 2. Selected Medicinal Plants in Vietnam.with PDA detector revealed the presence of 3 Science and Techniques Publishing House,main flavonoids (in total 60.43% of the extract) Hanoi, Vol. 1, P. 260 - 262 (1999).one of which was isolated and structurally 3. Phan Tong Son, Van Ngoc Huong, Phan Minhidentified as tiliroside on the basis of ESIMS, 1H Giang, Walter C. Taylor. Vietnam J. Chem.,NMR, 13C NMR spectra [5]. The other Vol. 37, No. 4, P. 1 - 2 (1999).constituents of the extract are diterpenoids 4. Phan Tong Son, Phan Minh Giang, Walter C.(12.5%) among which four ent-kaurane-type Taylor. Aust. J. Chem., Vol. 53, P. 1003 -diterpenoids were isolated and structurally 1005 (2000).characterized on the basis of ESIMS, FABMS, 1D 5. K. Y. Jung, S. R. Oh, S. H. Park, I. S. Lee, K.and 2D NMR including two new ent-1 -acetoxy- S. Ahn, J. J. Lee, and H. K. Lee. Biol. Pharm.7 ,14 -dihydroxykaur-16-en-15-one (1.26%) Bull., Vol. 21, P. 1077 - 1078 (1998).and ent-18-acetoxy-7 ,14 -dihydroxykaur-16- 6. N. B. Perry, E. J. Burgess, S. H. Baek, R. T.en-15-one (1.22%) together with two known ent-7 Weavers, W. Geis, A. B. Mauger. ,14 -dihydroxykaur-16-en-15-one (0.57%) [6] Phytochem., Vol. 50, P. 423 - 433 (1999). 12