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Although ubiquitously expressed, the transcriptional factor CP2 also exhib-its some tissue- or stage-specific activation toward certain genes such asglobin in red blood cells and interleukin-4 in T helper cells. Because thisspecificity may be achieved by interaction with other proteins, we screeneda peptide display library and identified four consensus motifs in numerousCP2-binding peptides: HXPR, PHL, ASR and PXHXH. Protein-databasesearching revealed that RE-1 silencing factor (REST), Yin-Yang1 (YY1)and five other proteins have one or two of these CP2-binding motifs....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Identification and characterization of four novel peptide motifs that recognize distinct regions of the transcription factor CP2
