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The complex C1 triggers the activation of the Complementclassical pathway through the recognition and binding ofantigen–antibody complex by its subunit C1q. The globularregion of C1q is responsible for C1 binding to the immunecomplex. C1q can also bind nonimmune molecules such asDNAand sulfated polysaccharides, leading either to theactivation or inhibition of Complement. The binding site ofthese nonimmune ligands is debated in the literature, and ithas beenproposed to be located either in the globular regionor in the collagen-like regionof C1q, or inboth....
Nội dung trích xuất từ tài liệu:
Báo cáo khoa học: Interaction of the C1 complex of Complement with sulfated polysaccharide and DNA probed by single molecule fluorescence microscopy
