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Guanylate cyclase-activating proteins (GCAPs) are neur-onal calcium sensors that activate membrane boundguanylate cyclases (EC 4.6.1.2.) of vertebrate photoreceptorcells when cytoplasmic Ca2+decreases during illumination.GCAPs contain fourEF-handCa2+-bindingmotifs, but thefirst EF-hand is nonfunctional. It was concluded that forGCAP-2, the loss of Ca2+-binding ability of EF-hand 1resulted in a region that is crucial for targeting guanylatecyclase [Ermilov,A.N.,Olshevskaya, E.V.&Dizhoor,A.M.(2001) J. Biol. Chem.276, 48143–48148]. In this study wetested the consequences of mutations in EF-hand 1 ofGCAP-1 with respect to Ca2+binding, Ca2+-induced con-formational changes and target activation. ...
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Báo cáo khoa học: Irregular dimerization of guanylate cyclase-activating protein 1 mutants causes loss of target activation
