Comparative study between the effects of some dietary sources and metformin drug on weight reduction in obese rats

The research aimed at comparative study between brown rice, germinated brown rice, and oat and metformin on overweight reduction in obese rats of lipid profiles (total cholesterol, triglycerides, low density lipoprotein (LDL-c), high density lipoprotein (HDL-c) and very low density lipoprotein (VLDL-c)) and liver function (Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT)) in rats.
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Comparative study between the effects of some dietary sources and metformin drug on weight reduction in obese ratsAnnals of Agricultural Science (2015) 60(2), 381–388 H O S T E D BY Faculty of Agriculture, Ain Shams University Annals of Agricultural Science www.elsevier.com/locate/aoasComparative study between the effects of somedietary sources and metformin drug on weightreduction in obese ratsZenab M. Mosa a,*, Y.A. El Badry a, Hala S. Fattah b, Eman G. Mohamed aa Nutrition and Food Sciences, Home Economics Dept., Fac. of Specific Education, Ain-Shams University, Egyptb Biochemistry and Nutrition Dept., Fac. of Women, Ain-Shams University, EgyptReceived 18 October 2015; accepted 2 November 2015Available online 30 December 2015 KEYWORDS Abstract The worldwide obesity epidemic has produced profound effects on public health. Grain Obesity; such as rice and oat may offer some protection against the early stage of obesity and the develop- Brown rice; ment of complications. The research aimed at comparative study between brown rice, germinated Oat; brown rice, and oat and metformin on overweight reduction in obese rats of lipid profiles (total Metformin; cholesterol, triglycerides, low density lipoprotein (LDL-c), high density lipoprotein (HDL-c) and Lipid profiles; very low density lipoprotein (VLDL-c)) and liver function (Aspartate Aminotransferase (AST) Liver function and Alanine Aminotransferase (ALT)) in rats. This work was carried out on 60 adult male white albino rats (Sprague-Dawley strain) randomly classified into ten groups. The results indicate that the statistical analysis referred that the positive control group was significantly increased in feed intake, triglycerides, HDL/LDL-cholesterol and VLDL-cholesterol comparing with group (3) (188.43 g and 98 g), (123.8 mg/dL and 117.3 mg/dL), (5.42 mg/dL and 0.439 mg/dL), (24.767 mg/dL and 23.467 mg/dL). On the other hand, group (6) in the relative weight heart, kidney and liver was significantly decreased comparing with positive control group (0.417 g and 0.517 g–0.8 g and 1.15 g–3.51 g and 5.65 g). Data represented showed that the significant increase in positive control groups comparing with group (4) of total lipids and glucose (208 mg/dL and 193.3 mg/dL) and (97.5 mg/dL and 76.5 mg/dL), while the positive control group was significantly increased in total cholesterol, HDL-cholesterol, ALT and AST comparing with group (6) (84.333 mg/dL and 56.333 mg/dL), (18.5 mg/dL and 7.167 mg/dL), (23.16 U/L and 13.5 U/L), and (130.5 U/L and 48.7 U/L). Ó 2015 Production and hosting by Elsevier B.V. on behalf of Faculty of Agriculture, Ain Shams University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/). Introduction * Corresponding author. E-mail address: Dr.Zenab@yahoo.com (Z.M. Mosa). The worldwide obesity epidemic has produced profoundPeer review under responsibility of Faculty of Agriculture, Ain-Shams effects on public health. Greater than two-thirds of AmericanUniversity. adults are currently reported to be overweight or obese (Flegalhttp://dx.doi.org/10.1016/j.aoas.2015.11.0010570-1783 Ó 2015 Production and hosting by Elsevier B.V. on behalf of Faculty of Agriculture, Ain Shams University.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).382 Z.M. Mosa et al.et al., 2008, 2012). In addition to increasing the incidence of control, a high fat diet; and GBR, a high fat diet plus 0.15%heart disease, stroke, and type 2 diabetes (T2D), epidemiologic GBR methanol extract for 7 week ...