Summary of Chemical doctoral thesis: Study on chemical constituents and biological activities of two species Markhamia stipulata var. canaenses V.S. Dang and Stereospermum binhchaunesis V.S. Dang of Bignoniaceae

The objectives of the thesis: Study on chemical constituents of two species Markhamia stipulata var. canaense V.S. Dang and Stereospermum binhchaunesis V.S. Dang; evaluation of biological activities of isolated compounds to find potential compounds.
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Summary of Chemical doctoral thesis: Study on chemical constituents and biological activities of two species Markhamia stipulata var. canaenses V.S. Dang and Stereospermum binhchaunesis V.S. Dang of Bignoniaceae 1MINISTRY OF EDUCATION VIETNAM ACADEMY AND TRAINING OF SCIENCE AND TECHNOLOGYGRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY ----------------------------- NG NGO TRONG NGHIA O STUDY ON CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF TWO SPECIESMARKHAMIA STIPULATA VAR. CANAENSE V.S.DANG AND STEREOSPERMUM BINHCHAUENSIS V.S. DANG OF BIGNONIACEAE Major: Chemistry of natural compounds Code: 9440117 SUMMARY OF CHEMICAL DOCTORAL THESIS HO CHI MINH, 2020This thesis was completed at: Graduate University Science andTechnology - Vietnam Academy of Science and TechnologyAdviser 1: Assoc. Prof. Dr. Mai Dinh TriAdviser 2: Assoc. Prof. Dr. Tran Cong Luan1st Reviewer:2nd Reviewer:3rd Reviewer:The thesis will be defended at Graduate University of Science andTechnology - Vietnam Academy of Science and TechnologyAt ……hour…….day……. month …….2020Thesis can be found in- The library of the Graduate University of Science and Technology,Vietnam Academy of Science and Technology.- The National library of Viet Nam 1 INTRODUCTION1. The urgency of the thesis Vietnam is a country located in the tropical monsoon region with anextremely rich and diverse plant source, including many valuable medicinal plantsthat our ancestors have used for a long time to treat a variety of diseases that showthe importance of medicinal plant resources. In recent years, according to thesocio-economic development, the demand for health care has been constantlyincreasing, scientists are going on looking for active substances with curativeproperties of natural origin. Many natural compounds have been isolated andwidely applied. They are used to produce medicines, plant protection drugs, asraw materials for food, pharmaceutical and cosmetic industries by safety, few sideeffects, environmentally friendly. Therefore, the search and study of the chemicalcomposition and biological activity of medicinal plants in order to detect attractiveactive compounds from herbs is a very necessary issue. The Markhamia and the Stereospermum genus of Bignoniaceae famila aredistributed in tropical and subtropical regions of Africa, China and SoutheastAsian countries such as Vietnam, Laos, Cambodia, and Thailand. The researchresults of some species in these 2 genus have discovered many interestingbiological properties such as hypoglycemia, antibacterial, anti-inflammatory,antioxidant, and analgesic ... Markhamia stipulata var. canaense V.S. Dang andStereospermum binhchauensis V. S. Dang are two newly discovered species in2015. Up to now, there have not been any studies on the chemical compositionand biological activity of the two species. So based on that science, we chose thetopic Study on chemical constituents and biological activities of two speciesMarkhamia stipulata var. canaenses V.S. Dang and Stereospermum binhchaunesisV.S. Dang of Bignoniaceae” contribute to the scientific basis for the study andapplication of these two species in the future. 22. The objectives of the thesis Study on chemical constituents of two species Markhamia stipulata var.canaense V.S. Dang and Stereospermum binhchaunesis V.S. Dang. Evaluation of biological activities of isolated compounds to findpotential compounds.3. The main contents of the thesis 1. Isolation of compounds from the leaves of Markhamia stipulata var.canaense V.S. Dang and Stereospermum binhchaunesis V.S. Dang. 2. Determination of chemical structures of the isolated compounds. 3. Evaluation on the cytotoxic activity and -glucosidase inhibiting of theisolated compounds. CHƯƠNG 1: OVERVIEW The overview of internal and international researches related to ourstudy. CHƯƠNG 2: METHODS 2.1. Plant materials The leaves of M. stipulata var. canaense V.S. Dang were collected in CaNa, Thuan Nam District, Ninh Thuan Province, Vietnam, in June 2016, andidentified by Dr. Van Son Dang, Institute of Tropical Biology. The leaves of S. binhchauensis V.S. Dang were collected in Binh Chau,Phuoc Buu District, Ba Ria Province, Vietnam, in June 2016, and identified by Dr.Van Son Dang, Institute of Tropical Biology. 2.2. Chemicals This section presents solvents and chemicals used in experiments 2.3. Isolation Methods This section presents methods for isolating pure compounds: thin-layerchromatography (TLC) and colum ...