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Salt-inducible kinase-1 (SIK1) is phosphorylated at Ser577by protein kinase A in adrenocorticotropic hormone-sti-mulated Y1 cells, and the phospho-SIK1 translocatesfrom the nucleus to the cytoplasm. The phospho-SIK1 isdephosphorylated in the cytoplasmand re-enters thenucleusseveral hours later. By using green-fluorescent protein-tag-ged SIK1 fragments, we found that a peptide region (586–612) was responsible for the nuclear localization of SIK1.Theregionwas namedtheRK-rich region because of itsArg- and Lys-rich nature. ...
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Báo cáo khoa học: Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm
