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Intraocular Drug DelIvery - part 6

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Biodegradable Systems177Figure 3 Cumulative release GCV from the scleral plugs of PLA-70,000 and PLA-5000 (whose content ratio was 80:20) containing 25% of GCV. The values shown are mean Æ SD. The duration of GCV release was prolonged further compared with the plug made of PLGA (75/25)-121,000. Abbreviations: GCV, ganciclovir; PLA, polylactic acid; PLGA, polyglycolic acid. Source: From Ref. 4.weight: 5000) at weight ratios of 80/20. These plugs included 25% GCV. The highmolecular-weight PLA may play a substantial role in the framework of the device and restrict the degradation rate of the low-molecular-weight PLA. Also the lowmolecular-weight PLA may regulate drug...
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Intraocular Drug DelIvery - part 6

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