Summary of Chemistry doctoral thesis: Chemical research and biological activity of two species of tai chua (Garcinia cowa Roxb. Ex Choisy) and dang hoang (Garcinia hanburyi Hook. F) growing in Vietnam

With the aim of searching for bioactive compounds from plants of the genus Garcinia in order to contribute to the scientific basis for further research in the pharmaceutical field, the thesis focuses on studying two species of the genus Garcinia is Garcinia cowa and Garcinia hanburyi.
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Summary of Chemistry doctoral thesis: Chemical research and biological activity of two species of tai chua (Garcinia cowa Roxb. Ex Choisy) and dang hoang (Garcinia hanburyi Hook. F) growing in Vietnam MINISTRY OF EDUCATION AND VIETNAM ACADEMY TRAINING OF SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY …………***………… NGUYEN THI KIM AN RESEARCH ON CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIESOF TWO SPECIES GARCINIA COWA ROXB. EX CHOISY AND GARCINIA HANBURYI HOOK. F GROWING IN VIETNAM Major: Chemistry of natural compounds Code: 9.44.01.17 SUMMARY OF CHEMICAL DOCTORAL THESIS HA NOI – 2020This thesis was completed at Graduate University of Science and Technology - Vietnam Academy of Science andTechnology.Supervisors: 1. Assoc.Prof. PhD. Ngo Dai Quang Institute of Natural Products Chemistry – Vietnam Academy of Science and Technology 2. Prof. PhD. Tran Thi Thu Thuy Institute of Natural Products Chemistry – Vietnam Academy of Science and TechnologyExaminer 1: Assoc.Prof. PhD. Phan Minh Giang University of Science – Vietnam National UniversityExaminer 2: Prof. PhD. Le Mai Huong Institute of Natural Products Chemistry – Vietnam Academy of Science and Technology The thesis defense was monitored by the Graduate University level Board of Examiners, held at: GraduateUniversity of Science and Technology - 18 Hoang Quoc Viet - Cau Giay - Ha Noi. At ……….. , ….………………….. 2020The thesis is available in Vietnam National Library and Library of Graduate University of Science andTechnology. 1 INTRODUCTION1. The urgency of the thesis Today, natural health protection and treatment aids are increasingly popular because they are safe to usebecause they have fewer side effects than synthetic products. Many natural compounds have been studied andisolated, determined their chemical structures and proven to have many important biological activities. Thesestudies not only contribute to the knowledge of compounds in nature, but also contribute to the detection ofpotential compounds, thereby building a conservation plan and development of suitable species. with the climateand soil of Vietnam.With a predominantly hot and humid climate, Vietnam is a suitable habitat for many valuable medicinal plantsthat have been used in folklore. Many species of the genus Garcinia have been used as medicinal herbs, forexample, dried yellow gamboge is used to treat cancer, hemostasis, deworming, respiratory inflammation ... ManyResearch on the chemical composition of species of the genus Garcinia has shown that their main chemicalcomposition is xanthone with many valuable biological activities such as cancer cell inhibitory activity, antioxidantactivity, and antibacterial properties, ... In Vietnam, the two trees of the genus Garcinia are the plant of the genusGarcinia (Garcinia cowa Robx. ex Choisy) and the tree gooseberry (Garcinia hanburyi Hook. f) of the Guttiferaefamily grow and develop very well, distributed in many localities across the country [1]. In the world, there havebeen many studies on the chemical composition and biological activity of these two species, but the sour ear tree(Garcinia cowa) and the rhubarb (Garcinia hanburyi) growing in Vietnam have not been collaborated. fake anyresearch.2. The research objectives of the thesis With the aim of searching for bioactive compounds from plants of the genus Garcinia in order to contributeto the scientific basis for further research in the pharmaceutical field, the thesis focuses on studying two speciesof the genus Garcinia is Garcinia cowa and Garcinia hanburyi. Therefore, the thesis: Chemical research andbiological activity of two species of tai chua (Garcinia cowa Roxb. Ex Choisy) and dang hoang (Garcinia hanburyiHook. F) growing in Vietnam. is implemented with the following main contents: - Isolation of compounds from Garcinia cowa latex. - Isolation of compounds from the latex and stems of Garcinia hanburyi. - Determination of the chemical structure of isolated compounds. - Investigate the kinetic and thermodynamic properties of gambogic acid as a basis for semi-synthesis ofsome derivatives of gambogic acid. - Investigate some biological activities of the compounds obtained.3. The main research contents of the thesis - Isolation and structural determination of compounds from Garcinia cowa latex and resin, tree trunksGarcinia hanburyi. - Investigate some of the kinetic and thermodynamic properties of gambogic acid - Synthesize some deriv ...